Piperidinium acetate → HCID 178518111, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1-[2,4-bis(trifluoromethyl)benzyl]piperidine-4-carbaldehyde (972 mg) in 2-propanol (20 mL) were added 4-({[4-(hydroxymethyl)tetrahydro-2H-pyran-4-yl]methyl}amino)thiazol-2(5H)-one (1.05 g) and piperidinium acetate (425 mg). The reaction mixture was stirred at 80° C. overnight and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane) and recrystallized from ethyl acetate/heptane to give the title compound (774 mg).

Provenance & Evidence