1-[2,4-Bis(trifluoromethyl)benzyl]piperidine-4-carbaldehyde → HCID 178518166, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1-[2,4-bis(trifluoromethyl)benzyl]piperidine-4-carbaldehyde (549 mg) in 2-propanol (5 mL) were added a solution of 4-[(trans-2-hydroxycyclohexyl)amino]thiazol-2(5H)-one (520 mg) in 2-propanol (5 mL) and piperidinium acetate (240 mg). The reaction mixture was stirred at 80° C. overnight, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane) and recrystallized from ethyl acetate/heptane to give the title compound (557 mg).

Provenance & Evidence