HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1620634Generated: November 2, 2026
Water → 1-[2,4-Bis(trifluoromethyl)benzyl]-5-(hydroxymethyl)azepan-2-one
https://huagongshe.com/reaction/1620634
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Lithium borohydride | HCID 4148881 | — |
| Reactant | Ethyl 1-[2,4-bis(trifluoromethyl)benzyl]-7-oxoazepane-4-carboxylate | HCID 86678800 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-[2,4-Bis(trifluoromethyl)benzyl]-5-(hydroxymethyl)azepan-2-one | HCID 86678801 | 90.3% |
Reaction Steps
To a solution of ethyl 1-[2,4-bis(trifluoromethyl)benzyl]-7-oxoazepane-4-carboxylate (14.8 g) in THF (400 mL) was added lithium borohydride (4.5 g). The reaction mixture was stirred at 50° C. for 1 hr, water was added, and the mixture was extracted with ethyl acetate. The extract was dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to give the title compound (12.0 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08772277B2 |
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| Source dataset | uspto-grants-2014_07 |
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| ORD ID | ord-395a40ceaad646bfaf3a6e47f2fc35d9 |
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| Source note | uspto-grants-2014_07 |
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