Piperidinium acetate → HCID 178484616, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1-[2,4-bis(trifluoromethyl)benzyl]piperidine-4-carbaldehyde (6.57 g) and N,N-dimethyl-N2-(2-oxo-2,5-dihydro-1,3-thiazol-4-yl)glycinamide (4.68 g) in 2-propanol (60 mL) was added piperidinium acetate (2.81 g). The reaction mixture was stirred at 80° C. for 4 hr and concentrated. Water was added to the residue, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (NH, ethyl acetate/hexane). The obtained solid was washed with diisopropyl ether and recrystallized from ethyl acetate/heptane to give the title compound (5.62 g).

Provenance & Evidence