HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1620642Generated: November 1, 2026
Piperidinium acetate → HCID 178514015, compound
https://huagongshe.com/reaction/1620642
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Piperidinium acetate | HCID 3014295 | — |
| Reactant | 1-[2,4-Bis(trifluoromethyl)benzyl]piperidine-4-carbaldehyde | HCID 86678663 | — |
| Reactant | HCID 178514014 | HCID 178514014 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | HCID 178514015 | HCID 178514015 | 15.7% |
Reaction Steps
To a solution of 1-[2,4-bis(trifluoromethyl)benzyl]piperidine-4-carbaldehyde (893 mg) in 2-propanol (20 mL) were added N2-(2-oxo-2,5-dihydro-1,3-thiazol-4-yl)-L-serinamide (1.07 g) and piperidinium acetate (195 mg). The reaction mixture was stirred at 60° C. overnight, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (methanol/ethyl acetate) to give the title compound (217 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08772277B2 |
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| Source dataset | uspto-grants-2014_07 |
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| ORD ID | ord-4ff2e10d0bef4a56b354179b334ef7f3 |
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| Source note | uspto-grants-2014_07 |
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