Piperidinium acetate → HCID 178484589, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1-[2,4-bis(trifluoromethyl)benzyl]piperidine-4-carbaldehyde (753 mg) in 2-propanol (10 mL) were added N2-(2-oxo-2,5-dihydro-1,3-thiazol-4-yl)-N,N-dimethyl-D-serinamide (770 mg) and piperidinium acetate (329 mg). The reaction mixture was stirred at 80° C. overnight, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (methanol/ethyl acetate) and silica gel column chromatography (NH, methanol/ethyl acetate) to give the title compound (371 mg).

Provenance & Evidence