Hydrogen chloride-ethyl acetate → HCID 178479765, compound

HRID 1620657Notes

Reaction equation

HRID 1620657 reaction equation
[F:1][C:2]([F:37])([F:36])[C:3]1[CH:31]=[C:30]([C:32]([F:35])([F:34])[F:33])[CH:29]=[CH:28][C:4]=1[CH2:5][N:6]1[CH2:11][CH2:10][CH:9](/[CH:12]=[C:13]2/[C:14]([NH:19][CH2:20][C:21]([O:23]C(C)(C)C)=[O:22])=[N:15][C:16](=[O:18])[S:17]/2)[CH2:8][CH2:7]1.[ClH:38].C(OCC)(=O)C>>[ClH:38].[F:37][C:2]([F:1])([F:36])[C:3]1[CH:31]=[C:30]([C:32]([F:34])([F:35])[F:33])[CH:29]=[CH:28][C:4]=1[CH2:5][N:6]1[CH2:7][CH2:8][CH:9](/[CH:12]=[C:13]2/[C:14]([NH:19][CH2:20][C:21]([OH:23])=[O:22])=[N:15][C:16](=[O:18])[S:17]/2)[CH2:10][CH2:11]1

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 178451231HCID 178451231, compound

Product 1

HCID 178479765HCID 178479765, compound

Procedure

A reaction mixture of tert-butyl N-[(5Z)-5-({1-[2,4-bis(trifluoromethyl)benzyl]piperidin-4-yl}methylidene)-2-oxo-2,5-dihydro-1,3-thiazol-4-yl]glycinate (13.3 g) and 4N hydrogen chloride/ethyl acetate (80 mL) was stirred at room temperature for 2 hr. The reaction mixture was concentrated to give the title compound (12.8 g).

Workup

  1. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-ce116918a37f46ee900cc1963fcbfae0
Source dataset
uspto-grants-2014_07
Patent number
US08772277B2

Reaction notes

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