Water → HCID 86678825, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-methyl-3-(trifluoromethyl)phenyl acetate (6.04 g) and 75% benzoyl peroxide (0.45 g) in (trifluoromethyl)benzene (60 mL) was added N-bromosuccinimide (5.42 g), and the mixture was stirred at 80° C. overnight. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The extract was washed with water and saturated brine, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate) to give the title compound (5.6 g).

Provenance & Evidence