4-Sulfanylidene-1,3-thiazolidin-2-one → HCID 178518170, compound

Participants

Reaction Steps

To a solution of (1S,2S)-2-aminocyclohexanol (1.00 g) in ethanol (30 mL) was added 4-thioxo-1,3-thiazolidin-2-one (1.17 g), and the mixture was heated under reflux overnight. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (786 mg).

Provenance & Evidence