HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1620683Generated: November 1, 2026
Piperidinium acetate → HCID 178462001, compound
https://huagongshe.com/reaction/1620683
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Piperidinium acetate | HCID 3014295 | — |
| Reactant | 1-[2,4-Bis(trifluoromethyl)benzyl]piperidine-4-carbaldehyde | HCID 86678663 | — |
| Reactant | HCID 178462003 | HCID 178462003 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | HCID 178462001 | HCID 178462001 | 37.3% |
Reaction Steps
To a solution of 1-[2,4-bis(trifluoromethyl)benzyl]piperidine-4-carbaldehyde (305 mg) and N,N-dimethyl-N2-(2-oxo-2,5-dihydro-1,3-thiazol-4-yl)-L-alaninamide (213 mg) in 2-propanol (2 mL) was added piperidinium acetate (144 mg) at room temperature. The reaction mixture was stirred at 60° C. overnight. The solvent was evaporated, and the residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (180 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08772277B2 |
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| Source dataset | uspto-grants-2014_07 |
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| ORD ID | ord-c6f26991b2c34b268cf51258d121acb1 |
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| Source note | uspto-grants-2014_07 |
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