4-Sulfanylidene-1,3-thiazolidin-2-one → HCID 178484550, compound

HRID 1620688Notes

Reaction equation

HRID 1620688 reaction equation
S=[C:2]1[CH2:6][S:5][C:4](=[O:7])[NH:3]1.Cl.[CH3:9][N:10]([CH3:16])[C:11](=[O:15])[CH2:12][CH2:13][NH2:14]>C(O)C>[CH3:9][N:10]([CH3:16])[C:11](=[O:15])[CH2:12][CH2:13][NH:14][C:2]1[CH2:6][S:5][C:4](=[O:7])[N:3]=1

Participants

4

Reactant 2

HCID 15395954-Sulfanylidene-1,3-thiazolidin-2-oneHCID 223644533-amino-N,N-dimethylpropanamide hydrochloride

Product 1

HCID 178484550HCID 178484550, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of N,N-dimethyl-R-alaninamide (2.12 g) in ethanol (25 mL) was added 4-thioxo-1,3-thiazolidin-2-one (2.43 g), which N,N-dimethyl-β-alaninamide hydrochloride was treated with AMBERLYST (registered trademark) A21, and the mixture was stirred at room temperature overnight. The reaction mixture was concentrated, and the residue was purified by silica gel column chromatography (NH, ethyl acetate/methanol) to give the title compound (0.33 g).

Workup

  1. additionwas treated with AMBERLYST (registered trademark) A21
  2. concentrationThe reaction mixture was concentrated
  3. customthe residue was purified by silica gel column chromatography (NH, ethyl acetate/methanol)

Sources & evidence

ORD record
ord-da1ffbcf55f84ad19c2903de37d7f420
Source dataset
uspto-grants-2014_07
Patent number
US08772277B2

Reaction notes

Loading…