Triethylamine → HCID 178455892, compound

Participants

Reaction Steps

To a solution of the crude product (19.4 g) containing N,N-dimethyl-L-isoleucinamide hydrochloride obtained in B) and triethylamine (49.5 g) in ethanol (150 mL) was added 4-thioxothiazolidin-2-one (16.3 g) at room temperature. The reaction mixture was stirred at room temperature for 3 hr. The solvent was evaporated under reduced pressure, the obtained solid was suspended in THF, and the suspension was filtered through celite pad and silica gel pad. The filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (NH, ethyl acetate/petroleum ether) to give the title compound (6.2 g).

Provenance & Evidence