Piperidinium acetate → HCID 178518153, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-[(2-hydroxyethyl)amino]-1,3-thiazol-2(5H)-one (1.20 g) and 1-[2,4-bis(trifluoromethyl)benzyl]piperidine-4-carbaldehyde (2.54 g) in 2-propanol (20 mL) was added piperidinium acetate (1.09 g) at room temperature. The reaction mixture was stirred at 60° C. overnight, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (NH, methanol/ethyl acetate) and recrystallized from ethyl acetate/heptane to give the title compound (1.12 g)

Provenance & Evidence