Piperidinium acetate → HCID 86678888, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (2S)—N,N-dimethyl-1-(2-oxo-2,5-dihydro-1,3-thiazol-4-yl)azetidine-2-carboxamide (682 mg) and 1-[2,4-bis(trifluoromethyl)benzyl]piperidine-4-carbaldehyde (1018 mg) is in 2-propanol (10 mL) was added piperidinium acetate (436 mg) at room temperature. The reaction mixture was stirred at 60° C. overnight, and the solvent was evaporated. The residue was purified by silica gel column chromatography (NH, ethyl acetate/hexane) and recrystallized from ethyl acetate/heptane to give the title compound (590 mg).

Provenance & Evidence