Piperidinium acetate → HCID 178448895, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1-[2,4-bis(trifluoromethyl)benzyl]piperidine-4-carbaldehyde (1.91 g) in 2-propanol (20 mL) were added 4-(but-3-yn-2-ylamino)-1,3-thiazol-2(5H)-one (1.42 g) and piperidinium acetate (834 mg). The reaction mixture was stirred at 75° C. for 6 hr and concentrated under reduced pressure. Water was added to the residue, and the mixture was extracted with ethyl acetate. The extract was washed with water and saturated brine, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (1.0 g).

Provenance & Evidence