Piperidinium acetate → HCID 86678903, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2,3,4,8-tetrahydro[1,3]thiazolo[3,4-a]pyrimidin-6-one (0.469 g) and 1-[2,4-bis(trifluoromethyl)benzyl]piperidine-4-carbaldehyde (1.12 g) in 2-propanol (10 mL) was added piperidinium acetate (0.479 g) at room temperature. The reaction mixture was stirred at 60° C. overnight, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (NH, ethyl acetate/hexane) and recrystallized from heptane to give the title compound (1.08 g).

Provenance & Evidence