Piperidinium acetate → HCID 178495009, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-methoxy-N,N-dimethyl-N2-(2-oxo-2,5-dihydro-1,3-thiazol-4-yl)-L-valinamide (460 mg) and 1-[2,4-bis(trifluoromethyl)benzyl]piperidine-4-carbaldehyde (628 mg) in 2-propanol (15 mL) was added piperidinium acetate (269 mg) at room temperature. The reaction mixture was stirred at 60° C. for 3 hr, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane) and recrystallized from ethyl acetate/heptane to give the title compound (380 mg).

Provenance & Evidence