Piperidinium acetate → HCID 178448315, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-{[(2S)-3-methyl-1-(morpholin-4-yl)-1-oxobutan-2-yl]amino}-1,3-thiazol-2(5H)-one (371 mg) and 1-[2,4-bis(trifluoromethyl)benzyl]piperidine-4-carbaldehyde (441 mg) in 2-propanol (10 mL) was added piperidinium acetate (189 mg) at room temperature. The reaction mixture was stirred at 60° C. overnight, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (NH, ethyl acetate/hexane) and recrystallized from ethyl acetate/heptane to give the title compound (416 mg).

Provenance & Evidence