Water → HCID 71246872, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of trans-3-benzyl-5,5-difluorohexahydro-1,3-benzoxazol-2(3H)-one (980 mg) in ethanol (60 mL)/water (6 mL) was added potassium hydroxide (411 mg). The reaction mixture was stirred at 80° C. overnight, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (methanol/dichloromethane) to give the title compound (540 mg).

Provenance & Evidence