4-Sulfanylidene-1,3-thiazolidin-2-one → HCID 178518175, compound

Participants

Reaction Steps

To a solution of trans-2-amino-4,4-difluorocyclohexanol (1.08 g) in ethanol (100 mL) was added 4-thioxo-1,3-thiazolidin-2-one (950 mg), and the mixture was heated under reflux for 15 hr. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (NH, ethyl acetate) to give the title compound (1000 mg).

Provenance & Evidence