Piperidinium acetate → HCID 178518174, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1-[2,4-bis(trifluoromethyl)benzyl]piperidine-4-carbaldehyde (777 mg) in 2-propanol (5 mL) were added 4-[trans-(5,5-difluoro-2-hydroxycyclohexyl)amino]-1,3-thiazol-2(5H)-one (860 mg) and piperidinium acetate (339 mg). The reaction mixture was stirred at 75° C. overnight, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane) and silica gel column chromatography (NH, methanol/ethyl acetate) to give the title compound (941 mg).

Provenance & Evidence