HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 2-(Chloromethyl)-5-methylpyridine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | (5-Methylpyridin-2-yl)methanol | HCID 12325387 | — |
| Product | 2-(Chloromethyl)-5-methylpyridine hydrochloride | HCID 23313795 | — |
Reaction Steps
Oxidation of 2,5-dimethylpyridine provides 2,5-dimethylpyridine N-oxide. Treatment of 2,5-dimethylpyridine N-oxide with acetic anhydride followed by base, such as, sodium hydroxide, provides (5-methyl-pyridin-2-yl)-methanol. (5-Methyl-pyridin-2-yl)-methanol is then treated with thionyl chloride to provide 2-chloromethyl-5-methyl-pyridine hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08772495B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-120755eb985844e7aa85f20422821353 |
| Source note | uspto-grants-2014_07 |