反应详情

2 M hydrochloric acid (45.0 mL) is added to a suspension of 7 (0.439 g, 1.32 mmol) in tetrahydrofuran (20.0 mL), and the suspension is warmed to reflux. The reaction became homogeneous upon heating. After refluxing for 4 hours, the reaction is allowed to cool to room temperature, and stood at room temperature overnight before the reaction is filtered. The filter pad is washed with water then dried in vacuo at 70° C. to give 9 as a white crystalline solid.

1. temperaturethe suspension is warmed to reflux
2. temperatureupon heating
3. temperatureAfter refluxing for 4 hours
4. filtrationis filtered
5. washThe filter pad is washed with water
6. customthen dried in vacuo at 70° C.