Hydrochloric Acid → 4-hydroxy-N-[5-(methylsulfinyl)-1,3-thiazol-2-yl]benzamide

HRID 1620888Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1620888
Cl.C([O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12](=[O:22])[NH:13][C:14]2[S:15][C:16]([S:19]([CH3:21])=[O:20])=[CH:17][N:18]=2)=[CH:8][CH:7]=1)(=O)C>O1CCCC1>[OH:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]([NH:13][C:14]2[S:15][C:16]([S:19]([CH3:21])=[O:20])=[CH:17][N:18]=2)=[O:22])=[CH:8][CH:7]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 569693934-{[5-(Methylsulfinyl)-1,3-thiazol-2-yl]carbamoyl}phenyl acetate

Produkt 1

HCID 569693954-hydroxy-N-[5-(methylsulfinyl)-1,3-thiazol-2-yl]benzamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

2 M hydrochloric acid (45.0 mL) is added to a suspension of 7 (0.439 g, 1.32 mmol) in tetrahydrofuran (20.0 mL), and the suspension is warmed to reflux. The reaction became homogeneous upon heating. After refluxing for 4 hours, the reaction is allowed to cool to room temperature, and stood at room temperature overnight before the reaction is filtered. The filter pad is washed with water then dried in vacuo at 70° C. to give 9 as a white crystalline solid.

Aufarbeitung

  1. temperaturethe suspension is warmed to reflux
  2. temperatureupon heating
  3. temperatureAfter refluxing for 4 hours
  4. filtrationis filtered
  5. washThe filter pad is washed with water
  6. customthen dried in vacuo at 70° C.

Quellen und Nachweise

ORD-Eintrag
ord-96ca542cf4184c7ca7c9e91b75f4d3ab
Quelldatensatz
uspto-grants-2014_07
Patentnummer
US08772502B2

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