HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 57446953, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 2,4-Difluorobenzaldehyde | HCID 73770 | — |
| Reactant | L-Leucinol | HCID 111307 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | HCID 57446953 | HCID 57446953 | — |
Reaction Steps
A solution of (S)-(+)-leucinol (2.47 g, 21 mmol) and 2,4-difluorobenzaldehyde (3 g, 21 mmol) in benzene (50 mL) was heated to reflux for 4 hours during which time water was collected in a Dean-Stark trap. The solvent was evaporated in vacuum to give (2S)-2-[(2,4-difluorobenzylidene)-amino]-4-methylpentan-1-ol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08772336B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-e087f98ea75e410f841b893f4840c9fa |
| Source note | uspto-grants-2014_07 |