HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 57515780, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2,2,2-Trifluoro-1-methoxyethanol | HCID 9892 | — |
| Reactant | HCID 74889769 | HCID 74889769 | — |
| Solvent | Benzene | HCID 241 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | HCID 57515780 | HCID 57515780 | — |
Reaction Steps
(L)-Norvalinol hydrochloride (5.25 g, 37.60 mmol) and trifluoroacetaldehyde methyl hemiacetal (5 mL, 37.6 mmol) were heated in benzene (100 mL) in the presence of triethylamine (5.26 mL, 37.6 mmol) at reflux, using a Dean-Stark apparatus to trap water. After 3 hours, the reaction mixture was cooled, diluted with ether (100 mL), filtered, and evaporated to dryness, giving (4S)-4-propyl-2-trifluoromethyloxazolidine, which was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08772336B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-50032139534a41ed9ced72752a99f13b |
| Source note | uspto-grants-2014_07 |