HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,4-Difluorobenzeneboronic acid → HCID 59715506, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,4-Difluorobenzeneboronic acid | HCID 2734337 | — |
| Reactant | HCID 59715504 | HCID 59715504 | — |
| Reactant | HCID 67298406 | HCID 67298406 | — |
| Catalyst | Palladium Chloride | HCID 24290 | — |
| Catalyst | Ferrocene-1,1'-bis-(diphenylphosphine) | HCID 635956 | — |
| Product | HCID 59715506 | HCID 59715506 | — |
Reaction Steps
The title compound was prepared in similar manner to that described for N1-(1-cyanocyclopropyl)-N2-{(1S)-2,2,2-trifluoro-1-[4′-(methylsulfonyl)-1,1′-biphenyl-4-yl]ethyl}-L-norvalinamide via Suzuki cross-coupling between 3,4-difluorophenylboronic acid and N2-[(1S)-1-(4-bromophenyl)-2,2,2-trifluoroethyl]-N1-(1-cyanocyclopropyl)-L-norvalinamide in the presence of 1,1′-bis(diphenylphosphino)ferrocene]-dichloropalladium(II), dichloromethane complex.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08772336B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-d933db0d47b14a08982e70a11d26961f |
| Source note | uspto-grants-2014_07 |