Sodium Thiosulfate → HCID 89524836, compound

Participants

Reaction Steps

The mixture of Example 86D (510 mg, 2.58 mmol) and Dess-Martin periodinane (1.3 g, 3.09 mmol) in 30 mL of dichloromethane was stirred under N2 atmosphere for 4 hours at room temperature. Then saturated NaHCO3 (120 mL) and Na2S2O3 (30 mL) was added with stirring for another 30 min. The mixture was extracted with dichloromethane (3×100 mL). The organic layers were combined, dried over Na2SO4, filtered, and concentrated to provide the crude product which was directly used in the next step without further purification.

Provenance & Evidence