Methanol → HCID 89524677, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of Example 140B (500 mg, 1.11 mmol) in dry MeOH (5 mL) was added NaBH4 (84 mg, 2.22 mmol) at 0° C. The mixture was stirred at 25° C. for 1 hour and water (10 mL) was added slowly. The aqueous phase was separated and extracted with dichloromethane (2×20 mL). The combined organic phases were washed with water, brine, dried over Na2SO4, filtered, and concentrated in vacuo. The resulting residue was purified by column chromatography on silica gel (petroleum ether/EtOAc=1/1) to give Example 140C.

Provenance & Evidence