2-Hydroxy-4-nitrobenzyl alcohol → 2-Hydroxy-4-nitrobenzaldehyde

HRID 1621028Notes

Reaction equation

HRID 1621028 reaction equation
[OH:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([N+:9]([O-:11])=[O:10])=[CH:5][C:4]=1[OH:12]>C(Cl)(Cl)Cl.[O-2].[Mn+4].[O-2]>[OH:12][C:4]1[CH:5]=[C:6]([N+:9]([O-:11])=[O:10])[CH:7]=[CH:8][C:3]=1[CH:2]=[O:1]

Participants

4

Reactant 1

HCID 118160942-Hydroxy-4-nitrobenzyl alcohol

Product 1

HCID 755702-Hydroxy-4-nitrobenzaldehyde

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6212ChloroformSolvent

Procedure

6.0 g (35.5 mmol) of 2-(hydroxymethyl)-5-nitrophenol and 3.1 g (35.5 mmol) of activated manganese(IV) oxide in 100 ml of chloroform are heated under reflux for 20 h. The mixture is filtered through kieselguhr, concentrated and dried under high vacuum. The title compound is immediately reacted further.

Workup

  1. temperatureunder reflux for 20 h
  2. filtrationThe mixture is filtered through kieselguhr
  3. concentrationconcentrated
  4. customdried under high vacuum
  5. customThe title compound is immediately reacted further

Sources & evidence

ORD record
ord-a6f3dc9c4c2d41afa33e45df052dea5e
Source dataset
uspto-grants-2014_07
Patent number
US08772511B2

Reaction notes

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