Lithium Hydroxide → HCID 86677477, compound

Participants

Reaction Steps

To a solution of dimethyl 1,2-dimethyl-1H-imidazole-4,5-dicarboxylate (1.89 g, 8.91 mmol) in THF (35 mL) and MeOH (15 mL) was added at 0-5° C. LiOH (1M; 9.35 mL, 9.35 mmol). The reaction mixture was stirred at RT for 7 h and the solvents were evaporated in vacuo. The residue was poured into water (20 mL) and ethyl acetate (30 mL). The ethyl acetate phase was washed with water (10 mL). The combined aqueous phases were acidified with hydrochloric acid (1M, 10 mL) and extracted with dichloromethane/MeOH (95:5, 8×60 mL). The dichloromethane/MeOH phases were dried over MgSO4, filtered and evaporated to give the product as colorless solid (1.29 g, 6.51 mmol, 73.1%). MS: M=199.1 (M+H)+

Provenance & Evidence