Morpholine → HCID 71288489, compound

HRID 1621092Notes

Reaction equation

HRID 1621092 reaction equation
[CH3:1][N:2]1[C:6]([C:7](=[O:21])[NH:8][CH2:9][CH2:10][C:11]2[N:15]([CH3:16])[C:14]3[CH:17]=[CH:18][CH:19]=[CH:20][C:13]=3[N:12]=2)=[C:5]([C:22](O)=[O:23])[N:4]=[C:3]1[CH3:25].[NH:26]1[CH2:31][CH2:30][O:29][CH2:28][CH2:27]1>>[CH3:16][N:15]1[C:14]2[CH:17]=[CH:18][CH:19]=[CH:20][C:13]=2[N:12]=[C:11]1[CH2:10][CH2:9][NH:8][C:7]([C:6]1[N:2]([CH3:1])[C:3]([CH3:25])=[N:4][C:5]=1[C:22]([N:26]1[CH2:31][CH2:30][O:29][CH2:28][CH2:27]1)=[O:23])=[O:21]

Participants

3

Reactant 2

HCID 8083MorpholineHCID 71279180HCID 71279180, compound

Product 1

HCID 71288489HCID 71288489, compound

Procedure

The product was obtained starting from 1,2-dimethyl-5-(2-(1-methyl-1H-benzo[d]imidazol-2-yl)ethylcarbamoyl)-1H-imidazole-4-carboxylic acid (51 mg, 149 μmol) and morpholine (39.0 μL, 448 μmol) according to the method described in example 8, step 3 as light brown waxy solid (17.3 mg, 42.1 μmol, 28.2%). MS: M=411.3 (M+H)+

Workup

  1. customThe product was obtained

Sources & evidence

ORD record
ord-4de4734239a54e9f8811e1e0c81f0607
Source dataset
uspto-grants-2014_07
Patent number
US08772510B2

Reaction notes

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