反应详情

The product was obtained starting from 2-(2-(5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)ethyl)isoindoline-1,3-dione (300 mg, 752 μmol) according to the method described in example 8, step 1 using 1.3 equivalents of potassium tert-butoxide and iodomethane with a reaction time of 16 h and after purification by flash chromatography (using silica gel and a MeOH/ethyl acetate gradient) as white solid (114.9 mg, 345 μmol, 45.9%). MS: M=334.1 (M+H)+

1. customThe product was obtained
2. customafter purification by flash chromatography (