Thiomorpholine → HCID 71288544, compound

HRID 1621122Notes

Reaction equation

HRID 1621122 reaction equation
[CH3:1][N:2]1[C:6]([C:7](=[O:23])[NH:8][CH2:9][CH2:10][C:11]2[N:12]=[C:13]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[O:14][C:15]=2[CH3:16])=[C:5]([C:24](O)=[O:25])[CH:4]=[N:3]1.[NH:27]1[CH2:32][CH2:31][S:30][CH2:29][CH2:28]1>>[CH3:16][C:15]1[O:14][C:13]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[N:12][C:11]=1[CH2:10][CH2:9][NH:8][C:7]([C:6]1[N:2]([CH3:1])[N:3]=[CH:4][C:5]=1[C:24]([N:27]1[CH2:32][CH2:31][S:30][CH2:29][CH2:28]1)=[O:25])=[O:23]

Participants

3

Reactant 2

HCID 67164ThiomorpholineHCID 71279111HCID 71279111, compound

Product 1

HCID 71288544HCID 71288544, compound

Procedure

The product was obtained starting from 1-methyl-5-(2-(5-methyl-2-phenyloxazol-4-yl)ethylcarbamoyl)-1H-pyrazole-4-carboxylic acid (40 mg, 113 μmol) and thiomorpholine (14.4 mg, 14.3 μL, 135 μmol) according to the method described in example 37, step 3 as colorless oil (41.7 mg, 94.9 μmol, 84.0%).

Workup

  1. customThe product was obtained

Sources & evidence

ORD record
ord-198af16731ef4596b58e73290258a1f3
Source dataset
uspto-grants-2014_07
Patent number
US08772510B2

Reaction notes

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