Carbon tetrabromide → HCID 86677486, compound

Participants

Reaction Steps

To a solution of (4-methyl-1-phenyl-1H-pyrazol-3-yl)methanol (158 mg, 0.84 mmol) and triphenylphosphine polymer bound (422 mg, 1.26 mmol) in dichloromethane (4.5 mL) was added carbon tetrabromide (416 mg, 1.26 mmol) at 0-5° C. The ice bath was removed after 15 min and the mixture was stirred at RT for 2 h. The mixture was filtered, washed with dichloromethane and the solvent was evaporated to give 426 mg crude material. The product was obtained after purification by flash chromatography (using silica gel and an ethyl acetate/heptane gradient) as light yellow oil (115 mg, 458 μmol, 38.3%).

Provenance & Evidence