Potassium Carbonate → HCID 71279219, compound

Participants

Reaction Steps

5-[2-Bis(tert-butoxycarbonyl)aminoethyl]-3-phenyl-[1,2,4]triazole (200 mg, 515 μmol; example 22, step 1) was dissolved in DMF (3.57 mL) and potassium carbonate (157 mg, 1.14 mmol) was added at RT. The mixture was stirred for 20 min, 2,2,2-trifluoroethyl trifluoromethanesulfonate (165 mg, 710 μmol) was added and stirring was continued at RT overnight. The reaction mixture was extracted with ethyl acetate (40 mL) and washed with water (3×20 mL) and brine (1×20 mL). The aqueous layers were back-extracted with ethyl acetate (40 mL) and the combined organic layer was dried over MgSO4 and concentrated in vacuo. The product was obtained after purification by flash chromatography (using silica gel and an ethyl acetate/heptane gradient) as white solid (140 mg, 378 μmol, 73.4%).

Provenance & Evidence