HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Ethoxycarbonyl)-1-methyl-1H-pyrazole-5-carboxylic acid → Ethyl 1-methyl-5-(2-(1-methyl-1H-benzo[d]imidazol-2-yl)ethylcarbamoyl)-1H-pyrazole-4-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Ethoxycarbonyl)-1-methyl-1H-pyrazole-5-carboxylic acid | HCID 25247567 | — |
| Reactant | 2-(1-methyl-1H-1,3-benzodiazol-2-yl)ethan-1-amine dihydrochloride | HCID 45075160 | — |
| Product | Ethyl 1-methyl-5-(2-(1-methyl-1H-benzo[d]imidazol-2-yl)ethylcarbamoyl)-1H-pyrazole-4-carboxylate | HCID 71279145 | — |
Reaction Steps
The product was obtained starting from 4-(ethoxycarbonyl)-1-methyl-1H-pyrazole-5-carboxylic acid (150 mg, 757 μmol, prepared as described in US 2011/0071128) and 2-(1-methyl-1H-benzo[d]imidazol-2-yl)ethanamine dihydrochloride (225 mg, 908 μmol) according to the method described in example 8, step 3 as red viscous oil (80 mg, 225 μmol, 29.7%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08772510B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-1245a3ac86b0474daa11c10b5f7f10fb |
| Source note | uspto-grants-2014_07 |