Lithium hydroxide, monohydrate → HCID 86677489, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1-methyl-1H-[1,2,3]triazole-4,5-dicarboxylic acid dimethyl ester (1 g, 5.025 mmol) in THF (20 mL) and ethanol (5 mL) was added at 0° C. a solution of lithium hydroxide monohydrate (169 mg, 4.02 mmol) in water (5 mL) over a period of 10 min. The reaction mixture was allowed to stir at 0° C. for 3 h. The mixture was diluted with water (10 mL) and washed with ethyl acetate (2×50 mL). The aqueous layer was evaporated under reduced pressure and the crude material thus obtained was dried by azeotropic distillation with toluene to afford the product as white solid (0.6 g, 3.24 mmol, 64.5%).

Provenance & Evidence