Hydrochloric Acid → HCID 71279237, compound

Participants

Reaction Steps

To a solution of methyl 1-methyl-5-(2-(1-methyl-4-phenyl-1H-imidazol-2-yl)ethylcarbamoyl)-1H-1,2,3-triazole-4-carboxylate (77 mg, 209 μmol) in THF (0.9 mL) and MeOH (0.3 mL) was added LiOH (1M aqueous solution, 418 μL, 418 μmol) at 0-5° C. The ice bath was removed and the mixture was stirred at RT for 4 h. HCl (1M aqueous solution, 0.42 mL, 0.42 mmol) was added and the solution was poured into dichloromethane (40 mL) to result in a suspension. The solid precipitate was filtered, washed with THF/water 4:1 and dried in vacuo to give the product as colorless solid (52 mg, 147 μmol, 70.2%).

Provenance & Evidence