Azetidine → HCID 71288598, compound

HRID 1621148Notes

Reaction equation

HRID 1621148 reaction equation
[CH3:1][N:2]1[C:6]([C:7](=[O:23])[NH:8][CH2:9][CH2:10][C:11]2[N:12]([CH3:22])[CH:13]=[C:14]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[N:15]=2)=[C:5]([C:24]([OH:26])=O)[N:4]=[N:3]1.[NH:27]1[CH2:30][CH2:29][CH2:28]1>>[CH3:22][N:12]1[CH:13]=[C:14]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[N:15]=[C:11]1[CH2:10][CH2:9][NH:8][C:7]([C:6]1[N:2]([CH3:1])[N:3]=[N:4][C:5]=1[C:24]([N:27]1[CH2:30][CH2:29][CH2:28]1)=[O:26])=[O:23]

Participants

3

Reactant 2

HCID 10422AzetidineHCID 71279237HCID 71279237, compound

Product 1

HCID 71288598HCID 71288598, compound

Procedure

The product was obtained starting from 1-methyl-5-(2-(1-methyl-4-phenyl-1H-imidazol-2-yl)ethylcarbamoyl)-1H-1,2,3-triazole-4-carboxylic acid (30 mg, 84.7 μmol) and azetidine (6.8 mg, 8 μL, 119 μmol) according to the method described in example 37, step 3 as colorless solid (11 mg, 28 μmol, 33%).

Workup

  1. customThe product was obtained

Sources & evidence

ORD record
ord-052f6ca86ff84471a0962ea7f5b4af87
Source dataset
uspto-grants-2014_07
Patent number
US08772510B2

Reaction notes

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