Water → HCID 71279191, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-(5-(chloromethyl)-3-phenyl-1H-1,2,4-triazol-1-yl)pyridine (130 mg, 480 μmol) and potassium cyanide (43.8 mg, 672 μmol) in DMSO (3.5 mL) was heated to 50° C. for 1.5 h. The cooled reaction mixture was poured into water (25 mL) and extracted with ethyl acetate (2×50 mL). The combined organic phase was washed with water (2×25 mL), dried over MgSO4 and concentrated in vacuo to give 110 mg crude product. The product was obtained after purification by flash chromatography (using silica gel and an ethyl acetate/heptane gradient) as white solid (30 mg, 114 μmol, 23.7%).

Provenance & Evidence