HCID 21758136, compound → HCID 71279166, compound

HRID 1621165Notes

Reaction equation

HRID 1621165 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[N:8][N:9]([CH3:14])[C:10]=1[C:11]([OH:13])=O)=[O:5])[CH3:2].Cl.Cl.[CH3:17][N:18]1[CH:22]=[C:21]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[N:20]=[C:19]1[CH2:29][CH2:30][NH2:31]>>[CH3:14][N:9]1[C:10]([C:11](=[O:13])[NH:31][CH2:30][CH2:29][C:19]2[N:18]([CH3:17])[CH:22]=[C:21]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[N:20]=2)=[C:6]([C:4]([O:3][CH2:1][CH3:2])=[O:5])[CH:7]=[N:8]1

Participants

3

Reactant 2

HCID 21758136HCID 21758136, compoundHCID 252475674-(Ethoxycarbonyl)-1-methyl-1H-pyrazole-5-carboxylic acid

Product 1

HCID 71279166HCID 71279166, compound

Procedure

The product was obtained starting from 4-(ethoxycarbonyl)-1-methyl-1H-pyrazole-5-carboxylic acid (200 mg, 1.01 mmol, prepared as described in US 2011/0071128) and 2-(1-methyl-4-phenyl-1H-imidazol-2-yl)ethanamine hydrochloride (288 mg, 1.21 mmol, example 7, step 4) according to the method described in example 37, step 1 as light yellow solid (252 mg, 661 μmol, 65.5%).

Workup

  1. customThe product was obtained

Sources & evidence

ORD record
ord-dd52945a0f2242ceb40f48865d0816d9
Source dataset
uspto-grants-2014_07
Patent number
US08772510B2

Reaction notes

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