HuagongsheHuagongshe Chemistry Print Report · For research reference only
Azetidine → HCID 71288686, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Azetidine | HCID 10422 | — |
| Reactant | HCID 71279119 | HCID 71279119 | — |
| Reactant | (1-Cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholino-carbenium hexafluorophosphate | HCID 75951468 | — |
| Product | HCID 71288686 | HCID 71288686 | — |
Reaction Steps
The product was obtained starting from 1-methyl-5-(2-(1-methyl-4-phenyl-1H-imidazol-2-yl)ethylcarbamoyl)-2-(trifluoromethyl)-1H-imidazole-4-carboxylic acid (30 mg, 71.2 μmol) and azetidine (4.98 mg, 5.88 μL, 85.4 μmol) via COMU coupling according to the method described in example 61, step 3 as white solid (20.5 mg, 44.5 μmol, 62.5%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08772510B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-3a43fad68c1c4aefbd692418d7408fa0 |
| Source note | uspto-grants-2014_07 |