Hydrogen Peroxide → HCID 68003850, compound

Participants

Reaction Steps

2-((4,6-difluoro-1H-indol-3-yl)thio)-N-(5-methylisoxazol-3-yl)acetamide (100 mg, 0.348 mmol) from Step C was dissolved in hexafluoro-2-propanol (500 μL) and hydrogen peroxide (30% by weight, 88.0 μL, 0.696 mmol). The mixture was stirred at ambient temperature for 2 hours. The reaction was quenched with saturated aqueous sodium sulfite (500 μL) and extracted with ethyl acetate (3×1 mL). The organics were combined, dried over magnesium sulfate, and concentrated in vacuo to give a residue which was purified on a silica gel column (0-100% ethyl acetate:hexanes over 19 min) to yield the desired product (79.0 mg, 0.174 mmol, 75% yield). LCMS>99% at 220 nm, RT=1.00 min, m/z=304 (M+1).

Provenance & Evidence