Hydrochloric Acid → 6-(6-Methoxypyridin-3-ylamino)-5-(4-methyl-6-(methylthio)-1,3,5-triazin-2-yl)nicotinaldehyde

Participants

Reaction Conditions

Reaction Steps

2 M Aqueous HCl (1.50 mL, 3.00 mmol) was added to a stirred solution of 5-(1,3-dioxolan-2-yl)-N-(6-methoxypyridin-3-yl)-3-(4-methyl-6-(methylthio)-1,3,5-triazin-2-yl)pyridin-2-amine (35 mg, 0.085 mmol) in THF (3.00 mL, 36.6 mmol) and the mixture was stirred at 25° C. for 2 h. A yellow precipitate gradually formed. The volatile solvents were minimized and the precipitate was collected and dried to give 6-(6-methoxypyridin-3-ylamino)-5-(4-methyl-6-(methylthio)-1,3,5-triazin-2-yl)nicotinaldehyde (27 mg, 0.073 mmol, 86% yield) as a yellow solid. LCMS (API-ES) m/z 369 (M+H)+.

Provenance & Evidence