反应详情

温度

-78 °C

3-Bromo-2-fluoro-5-((4-methoxybenzyloxy)methyl)pyridine (1.615 g, 4.952 mmol) was dissolved in PhMe (25.0 mL) and the reaction flask was cooled under nitrogen in a dry ice/acetone bath. Then, n-butyllithium solution (Fluka, Buchs, Switzerland, 1.6 M in hexane, 3.7 mL, 5.9 mmol) was added via syringe, turning the solution yellow. The reaction was stirred at −78° C. for 45 minutes and then triisopropyl borate (Alfa Aesar, Ward Hill, Mass. 98+%, 1.7 mL, 7.2 mmol) was added via syringe. The reaction was allowed to slowly warm up to room temperature, and after 90 minutes, the dry ice/acetone bath was removed. After another 25 minutes, the reaction was quenched with water and diluted with 10:1 DCM/MeOH. The biphasic solution was treated with 5N HCl to lower the pH of the aqueous phase from 9 to about 4, and the aqueous phase extracted with 10:1 DCM/MeOH. The organic extracts were concentrated and dried under high vacuum in water bath (about 45° C.-60° C.), and then the solid was washed with Et2O and dried again under high vacuum at room temperature over the weekend to afford 2-fluoro-5-((4-methoxybenzyloxy)methyl)pyridin-3-ylboronic acid (1.389 g, 68% purity, 66% yield). MS (ESI pos. ion) m/z 292 (M+H)+.

1. temperaturethe reaction flask was cooled under nitrogen in a dry ice/acetone bath
2. temperatureto slowly warm up to room temperature
3. waitafter 90 minutes
4. customthe dry ice/acetone bath was removed
5. waitAfter another 25 minutes
6. customthe reaction was quenched with water
7. additiondiluted with 10:1 DCM/MeOH
8. additionThe biphasic solution was treated with 5N HCl
9. extractionthe aqueous phase extracted with 10:1 DCM/MeOH
10. concentrationThe organic extracts were concentrated
11. dry with materialdried under high vacuum in water bath (about 45° C.-60° C.)
12. washthe solid was washed with Et2O
13. customdried again under high vacuum at room temperature over the weekend