5-Fluoro-3-pyridinamine → HCID 59548217, compound

HRID 1621769Notes

Reaction equation

HRID 1621769 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:14]=[C:13]([CH3:15])[N:12]=[C:11]([N:16](CC3C=CC(OC)=CC=3)CC3C=CC(OC)=CC=3)[N:10]=2)[C:5](F)=[N:6][CH:7]=1.[F:35][C:36]1[CH:37]=[C:38]([NH2:42])[CH:39]=[N:40][CH:41]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:14]=[C:13]([CH3:15])[N:12]=[C:11]([NH2:16])[N:10]=2)[C:5]([NH:42][C:38]2[CH:39]=[N:40][CH:41]=[C:36]([F:35])[CH:37]=2)=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 5744505-Fluoro-3-pyridinamineHCID 666005044-(5-chloro-2-fluoropyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine

Product 1

HCID 59548217HCID 59548217, compound

Procedure

The title compound was prepared in an analogous manner to that described in Example 246 using 4-(5-chloro-2-fluoropyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine and 5-fluoropyridin-3-amine (Matrix Scientific), and was isolated as an orange amorphous solid (10%). m/z (ESI, +ve ion) 332.0 (M+H)+. 1H NMR (400 MHz, d6-DMSO) δ 12.27 (1H, s); 8.77-8.84 (2H, m); 8.44-8.51 (2H, m); 8.21 (1H, d, J=2.5 Hz); 8.05 (1H, br. s.); 7.91 (1H, br. s.); 2.47 (3H, s).

Sources & evidence

ORD record
ord-3e39cb4046b34b01b6791097080a9024
Source dataset
uspto-grants-2014_07
Patent number
US08772480B2

Reaction notes

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