Benzophenone imine → N-(Diphenylmethylene)-5-fluoroquinolin-7-amine

Participants

Role	Name	HCID	Charge
Reactant	Benzophenone imine	HCID 136809	—
Reactant	Binap, (A+-)-	HCID 634876	—
Reactant	Sodium t-butoxide	HCID 23676156	—
Reactant	7-Bromo-5-fluoroquinoline	HCID 66600385	—
Catalyst	(1E,4E)-1,5-diphenylpenta-1,4-dien-3-one; palladium	HCID 6505921	—
Solvent	Toluene	HCID 1140	—
Product	N-(Diphenylmethylene)-5-fluoroquinolin-7-amine	HCID 86647070	—

Reaction Conditions

Temperature	110 °C

Reaction Steps

A mixture of 7-bromo-5-fluoroquinoline (128 mg, 0.566 mmol), benzophenone imine (0.143 mL, 0.849 mmol, Aldrich), Pd(dba)2 (32.6 mg, 0.057 mmol, Strem), 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (70.5 mg, 0.113 mmol, Aldrich) and sodium 2-methylpropan-2-olate (82 mg, 0.849 mmol, Aldrich) in toluene (4 mL) was stirred at 110° C. for

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08772480B2
Source dataset	uspto-grants-2014_07
ORD ID	ord-4bd939d802894b9eb17433a085516092
Source note	uspto-grants-2014_07