Benzene → Benzophenone

Participants

Reaction Conditions

Reaction Steps

38.3 g (277.4 mmol) of the benzene compound represented by the above formula (8) was added dropwise to a dichloromethane solution (400 ml) containing 38.8 g (291.2 mmol) of aluminum chloride and 40.9 g (291.2 mmol) of benzoyl chloride cooled to 0° C. After addition, the resulting mixture was stirred for 2 hours. After a reaction, the reaction product was washed with water, the solvent was removed, and the obtained product was purified by column chromatography to obtain a benzophenone derivative represented by the following formula (19) as 41.0 g (169.2 mmol, yield of 61%) of a white solid.

Provenance & Evidence