HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1622081Generated: November 2, 2026
3-Chloro-2-iodo-5-nitropyridine → 3-Chloro-5-nitropicolinonitrile
https://huagongshe.com/reaction/1622081
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-Chloro-2-iodo-5-nitropyridine | HCID 36995452 | — |
| Reactant | HCID 178418260 | HCID 178418260 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 3-Chloro-5-nitropicolinonitrile | HCID 21875495 | 94.3% |
Reaction Steps
A suspension of copper cyanide (7 g) and 3-chloro-2-iodo-5-nitro-pyridine (7 g) in acetonitrile (200 mL) was heated to 80° C. within 1 hour and stirred at 80° C. for 5 hours. The solvent was evaporated and the residue was filtered in ethyl acetate over silicon dioxide gave 3-chloro-2-cyano-5-nitro-pyridine (4.26 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08778625B2 |
|---|
| Source dataset | uspto-grants-2014_07 |
|---|
| ORD ID | ord-37fcca2047dd4e6fbd93267d86225677 |
|---|
| Source note | uspto-grants-2014_07 |
|---|
