HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1622083Generated: October 31, 2026
Bromine → 5-Amino-6-bromo-3-chloropicolinonitrile
https://huagongshe.com/reaction/1622083
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Bromine | HCID 24408 | — |
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | 5-Amino-3-chloropyridine-2-carbonitrile | HCID 21875099 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 5-Amino-6-bromo-3-chloropicolinonitrile | HCID 86588481 | 89.3% |
Reaction Steps
Bromine (7.22 g) was added to a stirring mixture of 5-amino-3-chloro-2-cyanopyridine (4.61 g) and sodium acetate (4.81 g) in anhydrous acetic acid (150 mL) at room temperature. The mixture was stirred at 60° C. for 2 hours. The solvents and excess bromine were evaporated and the residue was recrystallized from ethyl acetate to give 5-amino-6-bromo-3-chloro-2-cyano-pyridine (6.23 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08778625B2 |
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| Source dataset | uspto-grants-2014_07 |
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| ORD ID | ord-511306f0b06f4de09f9a30e72d706613 |
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| Source note | uspto-grants-2014_07 |
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